Safety of Intra-Articular Oxygen-Ozone Therapy Compared to Intra-Articular Sodium Hyaluronate in Knee Osteoarthritis: A Randomized Single Blind Pilot Study
This clinical trial was published in 2017 in Journal of Int J Phys Med Rehabil. by Italian specialists. The aim of this manuscript is to evaluate safety of intra-articular Oxygen-Ozone therapy and Intra articular Sodium hyaluronate in knee osteoarthritis.
Knee IA treatment with O2O3 showed shorter reduction of pain compared to IA HA. Despite IA administration of O2O3 and hyaluronan are comparable treatments in knee OA both in terms of safety and quality of life improvement, the latter shows longer times of pain reduction.