Management of Ankle Sprain with Single Periarticular Injection of Sodium Hyaluronate

Management of Ankle Sprain with Single Periarticular Injection of Sodium Hyaluronate

Article specifications

This Randomized controlled prospective trial was published in 2014 in Journal of BMJ (IF 2017:12.350) by Canadian and Spanish specialists. The aim of this study to evaluate the efficacy and safety of a single periarticular injection with SH in the treatment of lateral ankle sprain. A single-site, and non-controlled trial was conducted in patients with an acute grade 1 or 2 lateral ankle sprain. Patients received at baseline (within 48 hours of injury) a single 2.5ml periarticular injection with SH (manufactured by Tedec Meiji Farma SA) plus standard of care (RICE: Rest, Ice, Compression and Elevation). Efficacy assessments were done at baseline and days 8, 30 and 90 and included VAS (0-100mm) pain on weight bearing and walking 20m, patient's/physician's global assessment of ankle injury (5-point categorical scale), patient's assessment of return to normal activity in sport (5-point categorical scale), patient's/physician satisfaction with treatment (10-point categorical scale) and time to return to pain-free and disability-free sport. Adverse events were recorded for safety purposes. A total of 31 patients were included and completed the study.

 

Results

A single periarticular injection of SH showed significant reduction in pain, improved mobility and was highly satisfactory. This was associated with a rapid return to sport and with no safety concerns.

Tags: Spain Canada Annals of the Rheumatic Diseases 2014

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