The effects of Hyaluronic acid in the healing of Achilles Tendon repair
This clinical trial was published in 2003 in Journal of arthroscopy (IF 2016:4.292) by Turkish specialists. The aim of our study was to determine whether Hyaluronic acid (HA) treatment had a beneficial effect on the prevention of adhesion and possible role of collagen type IV synthesis of Achilles tendons in rabbits. Thirty-two male New Zealand rabbits underwent tenotomy and repair of the left Achilles tendon and were randomized into two groups. 0.5 ml HA or equivalent of saline was injected between the tendon and sheath. The right uninjured lower limb served as an internal control.
These findings show that exogenously applied HA may act as a modulator of Achilles tendon fibroblast proliferation, and collagen type IV production, indicating a possible mechanism for anti-adhesive effects following administration of tendon repair.