Modulation of Peritendinous Adhesions using Hyaluronic Acid and Autogenous Synovia: An Experimental Study in a Rabbit Model
This clinical trial was published in 2009 in Journal of Trends in Biomaterials and Artificial Organs (IF 2010:1.00) by Indian specialists. We evaluated the efficacy of hyaluronic acid (HA) and autogenous synovia (AS) in modulation of peritendinous adhesions following tendon injury in a rabbit model in vivo.
Observations revealed that proliferative and inflammatory responses were significantly reduced in HA and AS groups as well as early restoration of normal arrangements of collagen fibers, enhancement of neovascularization and the healing. Our finding suggests that the administration of HA and AS prevent the formation of peritendinous adhesions and improve the gliding function of the tendon.