Effect of high-dose vitamin C and Hyaluronic acid on tendon healing
Effect of high-dose vitamin C and Hyaluronic acid on tendon healing
Article specifications
This clinical trial was published in 2018 in Journal of Acta Ortop Bras (IF 2018: 0.87) by Turkish specialists. The aim of this study was assess the histopathologic and biomechanical effects of hyaluronic acid (HA) and high-dose vitamin C (VC) on rat Achilles tendon healing. Forty-eight Sprague-Dawley rats were randomized to HA and VC and control groups with equal numbers. Each group was further divided into two subgroups to be sacrificed on Day 15 (n=8) and Day 30 (n=8). The Achilles tendons were cut and repaired.
Result
Our results demonstrated that both VC and HA had therapeutic effects on tendon healing, especially in the late phase. Level of Evidence I; High quality randomized trial with statistically significant difference.