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Evaluate the effects of different concentrations and different molecular weights of HA (350 kDa, 1500 kDa, and 3000 kDa) on matrix metalloproteinase (MMP)-1 and -3 expression in IL-1β- stimulated rat tenocytes

High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy

Article specifications

This clinical trial was published in 2017 in Journal of Scientific Reports (IF 2014:4.122) by Taiwan specialists. This study aimed to evaluate the effects of different concentrations and different molecular weights of HA (350 kDa, 1500 kDa, and 3000 kDa) on matrix metalloproteinase (MMP)-1 and -3 expression in IL-1β- stimulated rat tenocytes, and on their dynamic expression in peritendinous effusion from patients with long head of biceps (LHB) tendinopathy after high-molecular-weight (HMW)-HA treatments.

 

Results

HA did not affect the proliferation or viability of tenocytes. HA3000 significantly attenuated the mRNA and protein expression of MMP-1 and -3 in IL-1β-stimulated tenocytes. In the present study, regardless of their molecular weight, none of our HA preparations increased or decreased the viability or proliferation of tenocytes. Therefore, HA is not cytotoxic for tenocytes. Moreover, HA3000 more significantly attenuated the mRNA and protein expression of MMP-1 and -3 in IL-1β-stimulated tenocytes than did HA preparations of other molecular weights.

Tags: Taiwan Clinical trial 2017 Scientific Reports

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