Effects of corticosteroid (CS) and hyaluronic Acid (HA) on torn rotator cuff tendon

Effects Of Corticosteroids And Hyaluronic Acid On Torn Rotator Cuff Tendon

Article specifications

This clinical trial was published in 2008 in Journal of J Orthop Res. (IF 2017:3.14) by Japanese specialists. The purpose of this study was to determine the effects of corticosteroid (CS) and hyaluronic Acid (HA) on torn rotator cuff tendon, using fibroblasts from human torn tendons (in vitro) and cuff tear model in rat (in vivo).

 

Results

Injections of CS and HA are used in the treatment of rotator cuff tears. It is well known that both drugs have an anti-inflammatory effect and can give pain relief, although the effects of these agents on tendon fibroblasts in the torn rotator cuff tendon has not been sufficiently clarified. As a result, CS significantly inhibited cell proliferation and decreased cell viability, compared with HA and controls. Concurred with the data from the in vitro analysis, CS inhibited the coverage by the fibrovascular tissue at the repaired site in rotator cuff tear model, consequently weakening the biomechanical strength at the site. On the other hand, HA did not show inhibitory effects in vitro and in vivo.