Cytoprotective effect of four different hyaluronic acids by molecular weight in human tenocytes

Nrf2-mediated cytoprotective effect of four different hyaluronic acids by molecular weight in human tenocytes.

Article specifications

This study was published in 2019 in Journal of J Drug Target. (IF 2017: 3.408) by Italian specialists. The aim of this study was to disclose a possible molecular mechanism underlying the cytoprotective effects of four different hyaluronic acid preparations (Artrosulfur HA^®, Synolis-VA^®, Hyalgan^® and Hyalubrix^®) under H₂O₂-induced oxidative stress.

 

Results

Results demonstrate that Artrosulfur HA, Hyalubrix and Hyalgan improve cell escape from H₂O₂-induced oxidative stress, decreasing cytotoxicity, reducing Nrf2 expression and enhancing catalase recovery. The present study lays the grounds for further investigations insight novel pharmaceutical strategies targeting key effectors involved in the molecular cascade triggered by hyaluronic acid.