Injectable Form of Cross-Linked Hyaluronan Is Effective for Middle Ear Wound Healing

Injectable Form of Cross-Linked Hyaluronan Is Effective for Middle Ear Wound Healing

Article specifications

This clinical Trial was published in 2015 in Journal of Annals of Otology, Rhinology & Laryngology (IF 2016: 1.17) by American specialists. The aim of this study was to evaluate the effect of hyaluronic acid in middle ear wound healing. This study was performed a comparison of hearing and ME inflammation in 3 groups. Group 1 (n = 8) underwent bilateral wounding of ME mucosa and unilateral packing of the ME with HA gel (Sepragel). Group 2 (n = 6) was the same as group 1 except that the packing was absorbable bovine collagen sponges (Gelfoam). Group 3, the control group (n = 14), had operated, unpacked ears. In a short-term study, we investigated ME retention of HA gel at 1 and 2 weeks (n = 16).

Results

In the present study, HA gel resulted in better ME microscopic findings in all categories than did ABC sponge. Hyaluronan gel was a relatively safe and effective ME packing material in our animal model.