Effectiveness of MeroGel hyaluronic acid on tympanic membrane perforations.

Article specifications

This original article was published in 2006 in Journal of Acta Otolaryngol. (IF 2014:1.40) by Turkish specialist. The purpose of this study was to evaluate the effectiveness of a single MeroGel application on traumatic tympanic membrane perforations in rats. The posterior quadrant of the tympanic membranes in both ears of 24 male pathogen-free Sprague-Dawley rats was perforated with a 20-gauge needle. Subjects were divided into two groups: MeroGel and daily topical HA-treated groups.

Results

Perforations of controls, and MeroGel- and daily HA-treated groups closed in 17/24 (70.8%), 11/12 (91.7%), and 12/12 (100%) ears, respectively. There was a significant difference between control and MeroGel-treated groups, and also between control and daily topical HA-treated groups for the presence of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), lymphocytes and collagen fibrils (p<0.05), whereas there was no significant difference between MeroGel- and daily topical HA-treated groups (p>0.05).

Tags: Turkey Acta Otolaryngol Original research 2006