Evaluate the clinical efficacy of hyaluronic acid applied to the nasal cavity after sinus surgery.

Hyaluronic acid for post sinus surgery care: systematic review and meta-analysis.

Article specifications

This systemic review was published in 2017 in Journal of Am J Otolaryngol. (IF 2015:0.44) by Australian specialists. A systematic review was performed to evaluate the current evidence on the clinical efficacy of hyaluronic acid applied to the nasal cavity after sinus surgery. Thirteen studies (501 patients) met the selection criteria. A meta-analysis of adhesion formation frequency on endoscopy demonstrated a lower risk ratio in the hyaluronic acid intervention group (42 out of 283 cases) compared to the control group (81 out of 282) of 0.52. Hyaluronic acid use was not associated with any significant adverse events.

 

Results

Hyaluronic acid appears to be clinically safe and well tolerated, and may be useful in the early stages after sinus surgery to limit adhesion rate. Further research, including larger randomised controlled trials, is required to evaluate patient- and clinician-reported outcomes of hyaluronic acid post sinus surgery.