An alternative treatment for the reduction of tympanic membrane perforations

An alternative treatment for the reduction of tympanic membrane perforations: sodium hyaluronate. A double blind study.

Article specification

This clinical trial was published in 1990 in Journal of Acta Otolaryngol. (IF2008: 1.48) by Spanish specialists. A double blind study comparing topical administration of 1% sodium hyaluronate with that of 2% methylcellulose solution (placebo). After treatment the degree of perforation healing was evaluated and expressed in percentage of reduction area.

 

Result

The reduced area turned out to be significantly different in the group treated with sodium hyaluronate solution as compared to the placebo group. Sodium hyaluronate is an alternative to myringoplasty for selected tympanic membrane perforations.