Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery

Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery.

Article specifications

This clinical trial was published in 2016 in Journal of Am J Rhinol Allergy. (IF 2015:1.43) by Italian specialists. This study aims to assess the effect of high-molecular-weight HA administered by aerosol on the morphofunctional recovery of ciliated cells damaged by surgical trauma. A single-blind, prospective, randomized trial was carried out with 94 patients who were randomly assigned, after endoscopic turbinoplasty, either to treatment with nasal saline solution irrigation (control group, n = 47) or to treatment with nasal douches based on high concentration (9 mg) and high-molecular-weight sodium hyaluronate (active treatment group, n = 47).

 

Results

Intranasal use of sodium hyaluronate in patients who underwent functional nasal surgery improved both mucociliary clearance and nasal mucosa regeneration due to a faster recovery of the impaired ciliated cells.