Effect of sodium hyaluronate on the nasal cytology of patients with rhinitis

Intranasal sodium hyaluronate on the nasal cytology of patients with allergic and nonallergic rhinitis.

Article specifications

This single-center, randomized, blinded trial was published in 2013 in American Journal of int forum allergy rhinol (IF 2016:1.955) by Italian specialist. The objective of this work was to determine the effects of intranasal administration of sodium hyaluronate on nasal cytology in patients with allergic and nonallergic rhinitis. 78 patients received intranasal mometasone and oral Desloratadine plus either intranasal sodium hyaluronate or saline for 1 month. Nasal cytology was performed and the change from baseline in the numbers of neutrophils, eosinophils, mast cells, lymphocytes, and infective species was determined. Other outcomes included changes in symptoms and the endoscopic appearance of the nasal mucosa, and tolerability, after 1 month of treatment.

 

Results

Patients receiving sodium hyaluronate experienced a significant decrease in the median neutrophil count seen on nasal cytology compared with controls. Sodium hyaluronate was associated with significant improvements in sneezing, rhinorrhea, and nasal congestion, and on exudate seen on endoscopy at 1 month compared with baseline. Intranasal sodium hyaluronate received better tolerability scores than saline over the 1-month treatment period.