Systematic Review of Hyaluronic Acid Effects on Upper Airway Inflammation in Pediatric Population

Hyaluronic Acid and upper airway inflammation in pediatric population: A systematic review

Article specifications

This systematic review was published in 2016 in International Journal of Pediatric Otorhinolaryngology (IF 2015:1.125) by Italian specialist. The aim of this work was to review the published literature regarding all the potential therapeutic effects of HA in the inflammatory disease of upper airway in pediatric population and evaluate the effectiveness of HA, alone or in combination, in children affected by cystic fibrosis. Relevant published studies about use of HA in UADT in pediatrics were searched in Pubmed, Google Scholar, Ovid using various keywords with no limit for the year of publication. Studies based on the use of HA with nasal packing and with invasive administration of HA were excluded. At the end of our selection process, four publications have been included: one of them in children with recurrent upper respiratory tract infections, one of them in children with bacterial acute rhino pharyngitis, two of them in children affected by cystic fibrosis.

 

Results

Data deriving from the present review of 4 clinical studies showed that HA could have a potential role in all the children affected by recurrent upper respiratory tract infections and cystic fibrosis to prevent reacutization, with a significant improvement of their quality of life. The strong connection between particle diameter and site of the high concentration of nebulized particles in the upper aero-digestive tract suggests that it should be mandatory to carefully chose the nebulizer device to get better therapeutic results.