Hyaluronic acid injections are associated with delay of total knee replacement surgery in patients with knee osteoarthritis

Hyaluronic Acid Injections Are Associated with Delay of Total Knee Replacement Surgery in Patients with Knee Osteoarthritis: Evidence from a Large U.S. Health Claims Database

Article specifications

This research study was published in 2015 in Journal of PLOS ONE (IF 2017: 2.766) by American specialists. The aim of this study was to evaluate the effect of hyaluronic acid injection for delay of total knee replacement surgery in patients with knee osteoarthritis. We retrospectively evaluated records in an administrative claims database of ~79 million patients, to identify all patients with knee OA who received TKR during a 6-year period. Only patients with continuous plan enrollment from diagnosis until TKR were included, so that complete medical records were available.

Results

HA injection in patients with knee OA is associated with a dose-dependent increase in time-to-TKR.