The antiadhesion/antibiofilm activity of hyaluronic acid and some of its derivatives to reduce/prevent bacterial adhesion

Hyaluronic acid and its composites as a local antimicrobial/antiadhesive barrier

Article specifications

This review article was published in 2017 in Journal of J. Bone Joint Infect. by Italian orthopedics. Aim of the present review is to summarize the available evidence concerning the antiadhesion/antibiofilm activity of hyaluronic acid and some of its derivatives to reduce/prevent bacterial adhesion and biofilm formation in various experimental and clinical settings.

 

Result

Considering the pathogenesis of implant-related infections, any protection offered by a fully biocompatible antiadhesive barrier, like HA and some of its derivatives, could be extremely useful to reduce the tremendous burden of implant-related infections.