ZrO₂ surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis

ZrO₂ surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry.

Article specifications

This clinical study was published in 2013 in Journal of Carbohydr Polym. (IF 2013: 4.59) by Korean dentists. This study describes the positive influences of ZrO(2) surface-modified with pcHAgel (Zr-3) containing two different loads of growth and differentiation factor-5 (GDF-5) to aid new bone formation as compared to the same amount of BMP-2 (Zr-4-7).

 

Results

The Zr-3 is a good biomaterial to deliver osteogenic differentiation factors such as BMP-2 and GDF-5, and GDF-5 can be useful as an effective alternative to aid new bone formation as compared to BMP-2.