Hyaluronic Acid as an Adjunct to Coronally Advanced Flap for The Treatment of Gingival Recession Defects

Hyaluronan As an Adjunct to Coronally Advanced Flap for The Treatment of Gingival Recession Defects.

Article specifications

This randomized clinical study was published in 2015 in National Journal of Integrated Research in Medicine (IF 2014:0.675) by Indian specialists. The present clinical trial was undertaken to evaluate the effectiveness of hyaluronon (HA) as an adjunct in root coverage procedures. 20 patients (13 females and 7 males) with millers class I and II gingival recession in a minimum of two sites were treated with HA gel combined with coronally advanced flap on the test site and sub epithelial connective tissue graft with CAF on the control sites. A single examiner performed the clinical measurements at baseline and at 1,3 and 9 months follow up. The following clinical measurements were recorded at the experimental teeth at baseline and at 1,3 and 9 months follow up using UNC-15 periodontal probe.

 

Results

Though growth factors can take away most of the credit for wound healing, HA appears to have a definite facilitating role as evident by the available literature. The undesirable biocompatibility, ease of handling, extent of healing, absence of complications, proved clinical parameters of HA makes it worth a material for future clinical research which requires a close collaboration among scientists and clinical dental researchers. To accelerate the chair-side application of HA in periodontal regenerative therapy further studies are expected with more stable and modified form of HA that can be developed by cross linking and coupling reactions.