Reduce Postoperative Adhesions with the use of Hyaluronic Acid Polymers

The Use of Hyaluronic Acid Polymers to Reduce Postoperative Adhesions

Article specifications

This clinical study was published in 1991 in Journal of GYNECOLOGIC SURGERY (IF 2003:0.73) by Japanese specialists. This study examines the ability of another proteoglycan, hyaluronic acid (HA) polymers (Pharmacia AB, Sweden), in four different formulations, to reduce adhesion formation in a rabbit model. New Zealand white rabbits underwent a midline laparotomy with bilateral ovarian bisection and were randomized to four treatment groups. Groups 1, 2, and 3 consisted of viscous solutions of HA polymers of differing molecular weights (2 ml applied to the treated ovary), and group 4 consisted of a polymer slab (2 × 2 cm piece applied to the treated ovary).

 

Result

None of the formulations of HA solutions resulted in a reduction of ovarian adhesions. Only the polymer slab significantly reduced adhesion formation.