The effect of retrobulbar hyaluronidase on hyaluronic acid gel-induced ophthalmic artery occlusion in a rabbit model

Role of Retrobulbar Hyaluronidase in Filler-Associated Blindness Evaluation of Fundus Perfusion and Electroretinogram Readings in an Animal Model.

Article specifications

This Prospective, Randomized, Single Masked, Parallel Study was published in 2018 in Journal of Ophthalmic Plast Reconstr Surg. (IF 2010:1.15) by American specialists. The purpose of this study is to determine the effect of retrobulbar hyaluronidase on hyaluronic acid gel-induced ophthalmic artery occlusion in a rabbit model. New Zealand red rabbits were used to simulate hyaluronic acid gel filler-associated vascular occlusive blindness. Retrobulbar hyaluronidase 1,000 IU was injected 30 minutes after occlusion. Fundus photography and electroretinogram changes were recorded at 30, 60, 90, and 120 after administration of retrobulbar hyaluronidase. A total of 6 rabbits were used, for a total of 12 eyes. Four eyes were used as controls. Four eyes were used as controls.

 

Results

In this rabbit model, 1,000 IU of retrobulbar hyaluronidase administered 30 minutes after occlusion failed to reverse obstruction or restore function following hyaluronic acid gel occlusion of the ophthalmic artery.