Compared the efficacy and safety of a 0.1% solution of hyaluronan with 0.9% saline

Double blind, randomised, placebo controlled,crossover, multicentre study to determine the efficacy of a 0.1% (wv) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome

Article specifications

This clinical trial was published in 1999 in Journal of Br J Ophthalmol. (IF 2014:2.83) by Britannia specialists. This study aimed to compared the efficacy and safety of a 0.1% solution of hyaluronan with 0.9% saline, when administered topically to the eye, in the treatment of symptoms of severe dry eye syndrome.

 

Results

No adverse events attributable to hyaluronan treatment were reported. This study demonstrates a clear benefit of hyaluronan over saline, in both subjective and objective assessments of dry eye syndrome. Hyaluronan was shown to be well tolerated.