Safety and efficacy of an eye drop combining osmoprotectants, carboxymethylcellulose and hyaluronic acid (O/CMC/HA) in reducing symptomatic, moderate to severe dry eye, compared with HA

Osmoprotectants, carboxymethylcellulose and hyaluronic acid multi-ingredient eye drop: A randomised controlled trial in moderate to severe dry eye.

Article specifications

This clinical trial was published in 2017 in Journal of Eye (IF 2017: 2.478) by France specialists. The aim of the present study was to assess the safety and efficacy of an eye drop combining osmoprotectants, carboxymethylcellulose and hyaluronic acid (O/CMC/HA) in reducing symptomatic, moderate to severe dry eye, compared with HA. Primary endpoint: mean change in Global Ocular Staining Score (GOSS) from baseline at day 35.

 

Result

O/CMC/HA is noninferior to HA in improving objective signs of dry eye, with potential advantages for subjective symptoms and patient acceptance. The results of this randomised, investigator-masked study demonstrate that in patients with moderate to severe dry eye, the combination of erythritol, CMC 0.5%, HA 0.1%, and glycerine in a preserved artificial tear formulation is noninferior to nonpreserved HA 0.18% alone in improving objective signs of dry eye as measured by the change in GOSS from baseline at day 35 in the PP population (primary endpoint)