Investigate in vitro the cell toxicity and antioxidant effects of two major tear substitutes, hyaluronic acid and a widely used carbomer, with and without preservative

Cytoprotective effects of hyaluronic acid and Carbomer 934P in ocular surface epithelial cells.

Article specifications

This study was published in 2002 in journal of Invest Ophthalmol Vis Sci. (IF2017: 3.388) by French ophthalmologists. The aim of this study was to investigate in vitro the cell toxicity and antioxidant effects of two major tear substitutes, hyaluronic acid and a widely used carbomer, with and without preservative.

 

Results

These two ophthalmic hydrogels have no cytotoxicity but possess antioxidant properties and tend to reduce the toxic effects of preservatives. These results may allow use of hydrogels, not only in dry eye but also in ocular surface disorders involving oxidative stress and in ophthalmic drug therapy to improve ocular tolerance.