Comparison of intra-articular injections of Hyaluronic Acid with Corticosteroid with bupavacine in the treatment of Osteoarthritis of the hip

Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors

Article specifications

This randomized, controlled study was published in 2010 in journal of BMC Musculoskeletal Disorders (IF 2016:2.11) by Belgian orthopedics.  Randomized, controlled trial with a three-armed, parallel-group design. 315 patients randomized into one of the following treatment groups: infiltration of the hip joint with hyaluronic acid, with a corticosteroid or with 0.125% bupivacaine. The following outcome measure instruments will be assessed at baseline, i.e. before the intra-articular injection of one of the study products, and then again at 6 weeks, 3 and 6 months after the initial injection. Pain (100 mm VAS), Harris Hip Score and HOOS, patient assessment of their clinical status (worse, stable or better then at the time of enrollment) and intake of pain rescue medication (number per week). In addition, patients will be asked if they have complications/adverse events. The six-month follow-up period for all patients will begin on the date the first injection is administered.

Results

This randomized, controlled, three-arm study will hopefully provide robust information on two of the intra-articular treatments used in hip osteoarthritis, in comparison to bupivacaine.