Biochemical effect of intra-articular injections of high molecular weight hyaluronate in rheumatoid arthritis patients.

Effect of intra-articular injections of high molecular weight hyaluronate in rheumatoid arthritis patients.

Article specifications

This clinical trial was published in 1999 in Journal of Inflamm Res. (IF 2015:1.27) by Japanese specialist. The purpose of this study was to analyze the biochemical characteristics of synovial fluids after treatment of patients with rheumatoid arthritis (RA) with intra-articularly injected hyaluronate (HA). In a double-blind study, 13 patients received intra-articular injections of 1% HA in phosphate buffered saline (PBS) while 13 other patients were injected 0.01% HA in PBS, as the control group. Injections were administered once a week for five weeks.

Results

Intra-articular HA injection altered the properties of synovial fluid and proved efficacious for patients with RA.