Comparisons for Nonsurgical Treatment of Knee Osteoarthritis

Mixed Treatment Comparisons for Nonsurgical Treatment of Knee Osteoarthritis: A Network Meta-analysis.

Article specifications

This meta-analysis was published in 2018 in Journal of J Am Acad Orthop Surg. (IF 2013: 3.46) by American specialists. A network meta-analysis to determine clinically relevant effectiveness of nonsteroidal anti-inflammatory drugs, acetaminophen, intra-articular (IA) corticosteroids, IA platelet-rich plasma, and IA hyaluronic acid compared with each other as well as with oral and IA placebos. PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were used to perform a systematic search of KOA treatments with no date limits and last search on October 7, 2015.

 

Result

Naproxen ranked most effective among conservative treatments of KOA and should be considered when treating pain and function because of its relative safety and low cost. The best available evidence was analyzed, but there were instances of inconsistency in the design and duration among articles, potentially affecting uniform data inclusion.