Delay of Knee Arthroplasty in Patients with Knee Osteoarthritis with Intra-Articular Injection of Synvisc

Is Intra-Articular Injection of Synvisc Associated with a Delay to Knee Arthroplasty in Patients with Knee Osteoarthritis?

Article specifications

This clinical trial was published in 2018 in Journal of Cartilage. (IF 2015: 1.00) by American specialists. Results of 4,027,848 knee OA patients, 141,305 patients underwent knee arthroplasty (KA). Overall median time from knee OA diagnosis to KA was 1.2 years. The Optum Clinformatics data set (2006-June 2016) was used to identify patients with knee osteoarthritis (OA). Patients who did not receive IA HA were identified, along with those who received Synvisc or non-Synvisc HA. The median duration from knee OA to KA was compared using quantile regression modeling with propensity score weighting.

 

Result

Most KA patients did not use HA (73.7%) and when received, it was associated with a longer median time to KA by at least 7 months, though the cause and effect could not be examined. The delay to KA increased with more HA courses.