Degradation alters the lubrication of articular cartilage by high viscosity, hyaluronic acid-based lubricants

Degradation alters the lubrication of articular cartilage by high viscosity, hyaluronic acid-based lubricants.

Article specifications

This study was published in 2018 in Journal of Cartilage. (IF 2017: 3.14) by Italian specialists. In this study we utilized a model of cartilage degradation by IL-1β along with a recently developed framework to study role of cartilage degradation on lubrication by clinically-approved HA-based lubricants with high viscosities. The tribological testing analyzed both boundary and mixed lubrication modes to assess individual effects of viscosity and boundary lubricating ability.

 

Result

This study revealed that lubrication of cartilage by HA is degradation-dependent and coincides with changes in mechanics and roughness.