The efficacy of multiple versus single hyaluronic acid injections

The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis.

Article specifications

This systematic review was published in 2017 in Journal of BMC Musculoskelet Disord. (IF 2013:1.18) by Indian and American specialists. A comprehensive literature search for relevant articles was conducted on February 26th, 2016 using a detailed search of the MEDLINE and EMBASE and PubMed databases. Secondary outcome was the number of treatment-related AEs and treatment-related serious adverse events (SAEs). We evaluated differences in levels of pain and AEs/SAEs between dosing regimens compared to IA-Saline.

 

Result

Overall, 2–4 and ≥5 injection regimens provided pain relief over IA-Saline. Intra-articular injections of HA used in a 2–4 injection treatment regimen provided the greatest benefit when compared to IA-Saline with respect to pain improvement in patients with knee OA, and were generally deemed safe with few to no treatment-related AEs reported across studies.