Treatment with NASHA is an effective and safe single-injection procedure in the clinical management of knee OA

Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis

Article specifications

This review study was published in 2018 in Journal of Open Access Rheumatol (IF 2014: 0.54) by Canadian, Australian, French and American specialists. This systematic evidence review examines patient outcomes following NASHA treatment as described in published data from studies conducted in subjects with knee OA. A Preferred Reporting Items for Systematic Reviews and Meta-analyses-compliant literature search strategy yielded 11 eligible clinical studies with a variety of comparator arms. Outcomes assessed at various time points following intra-articular treatment included measures of pain, function, quality of life, and incidence of treatment-related adverse events (AEs).

 

Result

The results of this clinical evidence review demonstrate that NASHA is most effective in reducing pain and improving function in patients with noninflammatory, unilateral, mild-to-moderate knee OA. Since NASHA is administered as a single injection, patient visits and associated costs, as well as potential risks associated with multiple injection courses, are reduced. The effects of NASHA treatment are long-lasting and likely to extend the length of time for non-operative treatment and increase the time the patient can live comfortably without undergoing joint replacement surgery.