Compare the chondroprotective effects of chondroitin sulfate (CS)-hyaluronic acid (HA) (CS-HA) injection and HA injection in an experimental model of osteoarthritis

Hyaluronic acid in combination with chondroitin sulfate and hyaluronic acid improved the degeneration of synovium and cartilage equally in rabbits with osteoarthritis.

Article specifications

This study was published in 2011 in Journal of Drug Discov Ther. (IF 2011:0.45) by Chinese specialists. The purpose of this study was to compare the chondroprotective effects of chondroitin sulfate (CS)-hyaluronic acid (HA) (CS-HA) injection and HA injection in an experimental model of osteoarthritis. In this study, we intended to explore the effects of CS injection and CS-HA compound injection on osteoarthritis in rabbits.

 

Result

The results of this study shows that after 5 intraarticular injections, the recovery of the synovial membrane of animals in the 'CS-HA' group was best among the animals treated with injections. These results suggest that the intra-articular application of CS-HA injection shows no obvious advantage over routine intra-articular HA therapy. CS-HA injection showed no obvious advantage over HA injection in osteoarthritis treatment.