Influence of Hyaluronic Acid on Normal and Osteoarthritic Tissue-Engineered Cartilage

Hyaluronic Acid Influence on Normal and Osteoarthritic Tissue-Engineered Cartilage.

Article specifications

This study was published in 2018 in Journal of Int J Mol Sci. (IF 2017:3.687) by Germany specialists. The aim of this study is to identify gene expression profiles associated with hyaluronic acid (HA) treatment of normal and osteoarthritis (OA)-like tissue-engineered cartilage.

 

Result

The present study can further confirm that HA has a minor physiological impact on normal and OA-like tissue-engineered cartilage compared to alterations caused by TNF-α. Nevertheless, it can possibly influence the cartilage anabolism via stabilizing the chondrocyte phenotype in pathological conditions. Moreover, the upregulation of VEGFA and ANKRD37 genes confirms the chondrostimulative potential of HA and slow down degradation. Understanding these HA-related modifications may serve as a guide toward imminent therapies. In addition to providing a more comprehensive picture of HA influence, the results in this study further validate the feasibility of in vitro OA model for the investigation of HA.