Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis

Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis: a systematic review and meta-analysis.

Article specifications

This review study was published in 2018 in Journal of J Shoulder Elbow Surg. (IF 2008:3.11) by Canadian and American specialists. We search in PubMed, MEDLINE, CENTRAL, and Embase were searched from the database inception date through January 16, 2018. Two reviewers independently screened articles for eligibility and extracted data for analysis. A methodological quality assessment was completed for all included studies, including assessment of risk of bias. The primary outcome was change in visual analog scale for pain. The secondary outcomes were functional outcome and adverse events.

 

Result

Intra-articular HA injection is safe and improves pain for patients with glenohumeral OA. Pain improvements also reported in the control group suggest that a significant placebo effect may be present with respect to intra-articular shoulder injection. Further randomized controlled trials are necessary to evaluate the efficacy of HA and identify optimal dosing and route of administration.