Identify biological, clinical or structural biomarkers of an intra-articular hyaluronic acid injection efficacy (HYMOVIS®)

Hyaluronan derivative HYMOVIS^® increases cartilage volume and type ii collagen turnover in osteoarhritic knee: data from MOKHA study

Article specifications

This pilot study was published in 2019 in Journal of BMC Musculoskeletal Disorders (IF 2018: 1.52) by Belgium specialists. The aim of this study was to identify biological, clinical or structural biomarkers of an intra-articular hyaluronic acid injection efficacy (HYMOVIS^®) for the design of a larger placebo-controlled clinical trial studying the disease-modifying activity of this treatment.

 

Results

HYMOVIS^®, a well-tolerated intra-articular treatment, significantly enhanced type II collagen turnover as suggested by the increase in Coll2–1 and PIIANP levels and cartilage volume observed by MRI in lateral knee compartment. Importantly, this study provides critical information for the design of a larger phase III clinical trial investigating Disease Modifying effect of HYMOVIS®.