Re-assess the safety profile of IAHA in patients with OA

Safety of Intra‑articular Hyaluronic Acid Injections in Osteoarthritis: Outcomes of a Systematic Review and Meta‑Analysis

Article specifications

This systematic review was published in 2019 in Journal of Drugs & Aging (IF 2017:2.381) by France, Belgium, American, Britain specialists. The aim of our study is to re-assess the safety profile of IAHA in patients with OA, through a comprehensive meta-analysis of randomized, placebo-controlled trials. A comprehensive literature search was undertaken in the databases MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus. Randomized, double-blind, placebo-controlled, parallel-group trials that assessed adverse events (AEs) with IAHA in patients with OA were eligible for inclusion.

 

Results

Using the available data on studies without any concomitant anti-OA medication permitted during clinical trials, IAHA seems not to be associated with any safety issue in the management of OA. However, this evidence was associated with only a "low" to "moderate" certainty. A possible association with increased risk of serious AEs, particularly when used with concomitant OA medications, requires further investigation.