Efficacy of HA and PRP in grade III and IV knee osteoarthritis

Intra-articular Hyaluronic Acid (HA) and Platelet Rich Plasma (PRP) injection versus Hyaluronic acid (HA) injection alone in Patients with Grade III and IV Knee Osteoarthritis (OA): A Retrospective Study on Functional Outcome

Article specifications

This clinical trial was published in 2016 in Journal of Malaysian Orthopaedic Journal by Malaysian specialists. This study analyses the efficacy of HA and PRP in grade III and IV knee osteoarthritis. This is a cross sectional study with retrospective review of 64 patients (101 knees) which includes 56 knees injected with HA+ PRP, and 45 knees with HA only.

 

Results

Our study is strongly suggestive that combination of HA and PRP to be more effective compared to HA alone. Hence, we suggest combination of intra-articular HA and PRP injection as an optional treatment modality in the treatment of grade III and IV knee osteoarthritis in terms of functional outcome and pain control for up to 6 months of duration when surgical treatment is not an option.