Efficacy and safety of periarticular hyaluronic acid in acute ankle sprain

Original research: long-term efficacy and safety of periarticular hyaluronic acid in acute ankle sprain.

Article specifications

This clinical Trial was published in 2009 in Journal of Phys Sportsmed. (IF 2013:2.29) by Canadian specialists. The aim of this randomized, controlled, prospective trial study was to evaluate the efficacy and safety of periarticular hyaluronic acid in acute ankle sprain. 158 competitive athletes who suffered an acute grade 1 or 2 lateral ankle sprain, and who were randomly assigned within 48 hours of injury involved in this study. Patients were randomly assigned at baseline to periarticular injection with HA + standard of care (rest, ice, elevation, and compression [RICE]) or placebo injection (PL) + standard of care (RICE) treatment at baseline assessment and day 4 after injury. Follow-up was at 30, 90, and 712 days after treatment.

 

Results

Periarticular HA treatment for acute ankle sprain was highly satisfactory in the short and long term versus PL. This was associated with reduced pain, more rapid return to sport, fewer recurrent ankle sprains, fewer missed days from sport, and with few associated AEs to 24 months.