Evaluate the reparative role of hyaluronic acid in acute rhinosinusitis (ARS)

Pathological and cytological changes of the nasal mucosa in acute rhinosinusitis: the role of hyaluronic acid as supportive therapy.

Article specifications

This clinical trial was published in 2017 in Journal of Eur Rev Med Pharmacol Sci. (IF 2015:1.76) by Italian specialists. The aim of this study was to evaluate the reparative role of hyaluronic acid in acute rhinosinusitis (ARS). 48 patients affected by ARS were submitted to nasal endoscopy, nasal cytology, mucociliary transport evaluation (MCTt) and visual analogue scale questionnaire (VAS) at T0, after 14-18 days (T1) and after 30-35 days (T2). The patients were randomized into two groups, A and B, and received Levofloxacin and Prednisone. Group A received high molecular weight Sodium Hyaluronate (3%) plus saline solution (NaCl 0.9%) twice a day for 30 days; Group B received saline solution twice a day for 30 days.

 

Results

The VAS score showed improvement in Group A. The VAS score showed statistically significant differences between the two groups regarding nasal discharge. In ARS patients sodium hyaluronate plus saline solution significantly improved symptoms, MCT time and reduced neutrophil count on nasal cytology.