Review articles of Hyaluronic acid effects on pressure ulcer

Hyaluronic Acid as a Treatment Option for Pressure Ulcers

Article specifications

This review article was published in 2013 in Wounds journal (IF 2016: 2.594) by Spanish specialists. The aim of this study was to review published reports on the clinical usefulness of hyaluronic acid in tissue regeneration and pressure ulcer (PU) healing. Literature searches were carried out using the dialog interface in the following databases: PubMed and Databases were searched from 2002 through 2012 for human studies. Those not appearing to meet key words were excluded and the others were reviewed in full. (43 references are listed as the literature in this article).

 

Results

More effective treatment options are required for PUs due to their elevated prevalence, negative impact on quality of life of patients, and high associated costs. There is wide scientific evidence on the positive role of hyaluronic acid and its sodium salts in tissue regeneration and wound healing. It maintains wound hydration and may neutralize the excess hyaluronidase in lesions and eliminate free radicals. High efficacy of hyaluronic acid was proven, particularly in the treatment of diabetic ulcers. Its use when treating PUs resulted in reduction of the ulcer size and a good tolerability and efficacy, but few data are available on its use to treat these wounds. Further research is warranted into the utilization of hyaluronic acid and related substances for PUs.