Efficacy of Hyaluronan in the Treatment of Pressure Ulcers

Efficacy and Tolerability of Hyaluronan (ialusetR) in the Treatment of Pressure Ulcers A Multicenter, Non-Randomized, Pilot Study

Article specifications

This multicenter, non-randomized, pilot study was published in 2007 in Drugs in R&D journal (IF 2015: 1.23) by French specialists. The purpose of this review was to investigate the efficacy and tolerability of ialusetR in the treatment of pressure ulcers. Male and female patients aged ≥18 years were included in the analysis if they had grade II, III or IV pressure ulcers (according to the National Pressure Ulcer Advisory Panel [NPUAP] system of classification) located anywhere on the body.  ialusetR cream or ialusetR gauze pads, over a 3-week period in ten hospitals in France, were used. Treatment type was determined by physicians for each patient according to the depth of the pressure ulcer; generally, ialusetR cream was used for deeper wounds. Treatment success was defined as a reduction in pressure ulcer surface area to of at least 95% during the treatment period. improvement was defined as a ≥50% increase in the epithelial surface compared with the initial area. Pain was evaluated on a 100mm visual analogue scale (VAS) in a total of 15 patients.

 

Results

Overall, the results obtained in this analysis suggest that ialusetR cream and gauze pads appear to be an effective method for treating pressure ulcers among patients with wounds unresponsive to other types of dressings.