Evaluation of hyaluronan gel (Gengigel(®) ) as a topical applicant in the treatment of gingivitis.
This clinical study was published in 2011 in Journal of J Investig Clin Dent. (IF 2014:1.08) by Indian dentists. The aim of this study was to evaluate the efficacy of clinically and histopathologically anti-inflammatory effect of 0.2% hyaluronan gel alone and with mechanical therapy on gingivitis. In each of the 28 gingivitis patients, the four quadrants were subjected to different treatments: scaling, scaling + topical hyaluronan gel, only topical hyaluronan gel, and topical + intrasulcular hyaluronan gel. Clinical parameters were recorded at baseline, and on days 7, 14, and 21. Biopsies were taken from each quadrant, inflammatory infiltrates were graded, and the argyrophilic nucleolar organizer region count was measured before and after treatment.
Hyaluronan gel is an effective topical agent for treating gingivitis, along with scaling and intrasulcular application. The argyrophilic nucleolar organizer region count can be used as a histopathological indicator in cases of non-responsive gingivitis to assess the severity of gingival inflammation.