Effect of various molecular weights of HA on P. gingivalis-induced inflammatory and wound-healing responses in human gingival fibroblasts (HGFs)

High molecular weight hyaluronic acid regulates P. gingivalis-induced inflammation and migration in human gingival fibroblasts via MAPK and NF-κB signaling pathway.

Article specifications

This study was published in 2018 in Journal of Arch Oral Biol. (IF 2009:2.37) by Chinese specialists. This study aimed to investigate the effect of various molecular weights of HA (30, 300 and 1300 kDa) on P. gingivalis-induced inflammatory and wound-healing responses in human gingival fibroblasts (HGFs).

Results

The results showed that P. gingivalis (1.6 × 106 CFU/mL) and HA (1, 2, 5 and 10 mg/mL) exhibited no toxicity to the HGFs. The 1300 kDa HA inhibited P. gingivalis-induced IL-1β, IL-6, IL-8, IL-4 and IL-10 production in a dose-dependent manner, while the 30 and 300 kDa HA did not have an effect. High molecular weight HA may have beneficial effects on periodontal inflammation and oral wounds.