Effects of Topical Subgingival Hyaluronic Acid Gel in Chronic Periodontitis

Clinical and Microbiological Effects of Topical Subgingival Application of Hyaluronic Acid Gel Adjunctive to Scaling and Root Planting in the Treatment of Chronic Periodontitis.

Article specifications

This clinical and microbiological study was published in 2004 in journal of Periodontology (IF 2013:4.86) by Chinese and German specialists. The aim of this study was to evaluate whether the application of HA gel could enhance the results obtained by SRP only in patients with chronic periodontitis. 20 patients (mean 48.6 years, 11 males and nine females, the patients had at least 20 natural teeth and two sites in each quadrant with a minimum probing depth of 5 mm. Patients were not included in this study if their systemic health precluded periodontal treatment or if they were pregnant, or had previous periodontal and/or antibiotic therapy in the last 6 months.) with chronic periodontitis were included in this split-mouth study. Sulcus fluid flow rate (SFFR) and sulcus bleeding index were monitored at baseline and after 1, 2, 3, 4, 5, 6, and 12 weeks; probing depth and clinical attachment level were monitored at baseline and 6 and 12 weeks. Subgingival plaque samples were also taken at these same three appointments to determine the presence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, and Treponema denticola. All patients were treated with full-mouth scaling and root planing (SRP); in addition, an HA gel was administered subgingivally in the test sites every week for 6 weeks.

 

Results

No clinical or microbiological improvement was achieved by the adjunctive use of HA gel compared to SRP alone. Only SFFR was affected by the use of HA in terms of a more rapid reduction of SFFR in the test sites. Hyaluronic acid showed positive effects in influencing local inflammation.