hyaluronan gel in conjunction with periodontal surgery

Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial.

Article specifications

This randomized clinical study was published in 2012 in Journal of Clinical Oral Investigations (IF 2012:1.77) by German and Egyptian specialists. The aim of the current study was to clinically evaluate the effect of local application of hyaluronan gel in conjunction with periodontal surgery. Fourteen patients with chronic periodontitis having four interproximal intrabony defects (≥3 mm) with probing depth values >5 mm were included in this split-mouth study. Following initial nonsurgical periodontal therapy and re-evaluation, defects were randomly assigned to be treated with modified Widman flap (MWF) surgery in conjunction with either 0.8% hyaluronan gel (test) or placebo gel (control) application. Clinical attachment level (CAL), probing depth (PD), gingival recession (GR), plaque index (PI), and bleeding on probing (BOP) values were taken at baseline and 3 and 6 months. Differences between test and control sites were evaluated using a Wilcoxon signed-rank and a McNemar test. A Friedman and a Cochran test were used to test equal ranks over time.

 

Results

Statistically significant differences were noted for CAL and GR in favor of the test sites. No significant differences were found regarding PD, BOP, or PI values. Hyaluronan gel application in conjunction with periodontal surgery appears to result in significant improvement of CAL and in a reduction in GR. Hyaluronan gel application in conjunction with periodontal surgery appears to significantly favor the periodontal surgical outcome in terms of a gain in clinical attachment level as well as a reduction in gingival recession values.