Efficacy of Hyaluronic Acid Gel in Pain Control of Recurrent Aphthous Stomatitis

The Efficacy of Hyaluronic Acid Gel in Pain Control of Recurrent Aphthous Stomatitis.

Article specifications

This clinical study was published in 2016 in International Journal of Dentistry and Oral Science (IF 2015:2.46) by Turkish specialists. This study was conducted to evaluate the efficacy of topical hyaluronic acid gel (HA) and compared with triamcinolone acetonide pomade (TA) in the treatment and pain control of RAS. A total of 57 patients with a history of RAS and currently suffering from oral ulcer were selected from patients referred to clinic. The subjects randomly divided into two groups; one group have received HA gel the other group conceived TA pomade. All patients were instructed to apply the agents to the ulcer 4 times per day for 7 days (day 0 to day 6). To evaluate pain level, a visual analog scale (VAS) was used.

 

Results

Although there was no statistical difference between two groups by means of mean ulcer VAS scores at day 0, significant differences were found at day 4 and day 7. The ulcer pain score (VAS) of two groups decreased within time however, the pain score in HA group was statistically lower than that of the TA groups at day 4 and 7. HA gel reduced the painful symptoms of RAS when compared with TA pomade. These outcomes suggest that HA gel can be effectively used for pain control in RAS treatment.