Review article of Hyaluronic acid effects on burn treatment
Hyaluronic acid covers in burn treatment: a systematic review
Article specifications
This review article was published in 2016 in journal of Rev Esc Enferm USP (IF 2015:1.51) by brazilian specialists. This meta-analysis was designed to evaluate the effectiveness of hyaluronic acid in the healing of partial thickness burns. The relevant studies were found by searching in the following electronic databases: Medical Literature Analysis and Retrieval System Online/PubMed (MEDLINE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, Literature in the Health Sciences in Latin American and the Caribbean (LILACS), Cochrane Central Register of Controlled Trials (CENTRAL) and Excerpta Medica Database (EMBASE). This review included randomized controlled trials, published or not, with any sample size that contemplated the adoption of hyaluronic acid in the treatment of skin burns of partial thickness or deep partial thickness, regardless of the mechanism of injury, depth, location or body surface area burned in hospitalized children, adolescents, adults and elderly. Two randomized controlled trials that analyzed 143 patients with partial thickness burns and/or deep partial thickness burns were selected.
Results
This review emphasizes the need for new well-designed randomized controlled trials to establish the therapeutic relevance of hyaluronic acid with respect to the healing of burns of partial thickness or deep partial thickness. the topical action of the combination of hyaluronic acid and silver sulfadiazine showed significantly favorable response in relation to the average healing time of partial thickness burns or deep partial thickness burns. In addition, there was no occurrence of adverse effects or side effects, thus suggesting the possibility for the clinical use of the product in terms of effectiveness and safety.
