Systematic Review articles of Hyaluronic acid effects on chronic wounds

Effectiveness of hyaluronic acid and its derivatives on chronic wounds: a systematic review

Article specifications

This review article was published in 2016 in journal of wound care (IF 2016:1.205) by Malaysian pharmacists. The aim of this study was to provide more updated evidence for the effectiveness of HA (or its derivatives) compared with placebo or other agents for promoting healing in chronic wounds. The Cochrane Central Register of Controlled Trials, MEDLINE via Ovid Online, CINAHL and the EMBASE via EBSCO host databases were searched. Drug companies and experts in wounds were also contacted. Randomized controlled trials of HA (or its derivatives) compared with control were eligible for inclusion. This study identified nine randomized controlled trials involving 865 participants with chronic wounds were included in the review.

 

Results

This meta-analysis contains some evidence on HA or its derivatives effectiveness especially on reducing pain intensity. The availability of high-quality evidence is still limited. Additionally, RCTs need to use the revised CONSORT statement in order to improve the quality of reporting RCTs.