Safety and effectiveness of a new collagenase produced by Vibrio algynoliticum

A new association between hyaluronic acid and collagenase in wound repair: an open study.

Article specifications

This clinical trial was published in 2013 in Journal of Eur Rev Med Pharmacol Sci. (IF 2013: 1.49) by Italian specialists. The aim of this study was to evaluate the safety and the effectiveness of a new collagenase produced by Vibrio algynoliticum. Forty patients were enrolled and daily treated for five weeks with Bionect Start® ointment. Parameters took into account were fibrin degradation and pain relief. The same team carried out treatment during the study period of five weeks.

 

Results

The application of this product on the lesions promotes vascularized granulation tissue and reduces formation of fibrin and exudate. Furthermore, a macroscopical margins proliferation is highlighted after a short time and an improvement of periwound skin is observed during the treatment period. Bionect Start® allowed easy removal of dressing, less pain for patient, reduction of dressing time.