Treatment of venous leg ulcers with Hyalofill-F (a partial benzyl ester derivative of hyaluronan), used in combination with compression bandaging

A trial to assess the efficacy and tolerability of Hyalofill-F in non-healing venous leg ulcers.

Article specifications

This clinical trial was published in 2003 in Journal of J Wound Care. (IF2003: 0.25) by Italian specialists. The aim of the study was to assess the efficacy and tolerability of Hyalofill-F (a partial benzyl ester derivative of hyaluronan), used in combination with compression bandaging, in the treatment of venous leg ulcers. The 20 patients enrolled into the study had venous insufficiency and a leg ulcer that had been refractory to treatment for one month. Treatment was continued for eight weeks, with weekly assessments.

 

Results

The hyaluronan derivative showed promising results in initiating the healing process in chronic venous ulcers. It was found to be well tolerated and safe to use. However, further clinical trials should be performed involving a control group to verify these data.